929040-21-1

Basic information

• Product Name: E-5-[5-(2-Fluoro-4-pyridinyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide
• Synonyms: E-5-[5-(2-Fluoro-4-pyridinyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide
• CAS NO: 929040-21-1
• Molecular Weight: 526.514
• Mol File: 929040-21-1.mol

Chemical Properties

• CAS DataBase Reference: E-5-[5-(2-Fluoro-4-pyridinyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: E-5-[5-(2-Fluoro-4-pyridinyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide(929040-21-1)
• EPA Substance Registry System: E-5-[5-(2-Fluoro-4-pyridinyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide(929040-21-1)

Safety Data

• Hazardous Substances Data: 929040-21-1(Hazardous Substances Data)

Upstream product

• 929040-18-6 5-(5-bromo-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxamide 
• 401815-98-3 2-fluoropyridin-4-ylboronic acid 

Downstream Products

• 1032198-85-8 1,1-dimethylethyl {2-[(4-{1-[5-(aminocarbonyl)-4-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thienyl]-1H-benzimidazol-5-yl}-2-pyridinyl)amino]ethyl}methylcarbamate 
• 1032198-55-2 5-[5-(2-{[3-(Dimethylamino)propyl]amino}-4-pyridinyl)-1H-benzimidazol-1-yl]-3-([(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]oxy)-2-thiophenecarboxamide 
• 1032198-51-8 5-[5-(2-{[2-(Dimethylamino)ethyl]amino}-4-pyridinyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}-oxy)-2-thiophenecarboxamide 
• 1032198-88-1 1,1-dimethylethyl {2-[(4-{1-[5-(aminocarbonyl)-4-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thienyl]-1H-benzimidazol-5-yl}-2-pyridinyl)amino]ethyl}carbamate 
• 1032198-57-4 5-(5-{2-[[2-(Dimethylamino)ethyl](methyl)amino]-4-pyridinyl}-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide 
• 929040-16-4 5-{5-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-benzimidazol-1-yl}-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxamide 

Relevant articles and documents

5- AND 6- SUBSTITUTED BENZIMIDAZOLE THIOPHENE COMPOUNDS

The present invention provides 5- and 6-substituted benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK MODULATORS

The present invention provides 5-heteroaryl substituted benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES

The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.