929040-32-4

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 5-(5-bromo-1H-benzimidazol-1-yl)-3-[(1R)-1-(2-chlorophenyl)ethoxy]-, methyl ester
• CAS NO: 929040-32-4
• Molecular Formula: C21H16BrClN2O3S
• Molecular Weight: 491.793
• Mol File: 929040-32-4.mol

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 5-(5-bromo-1H-benzimidazol-1-yl)-3-[(1R)-1-(2-chlorophenyl)ethoxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 5-(5-bromo-1H-benzimidazol-1-yl)-3-[(1R)-1-(2-chlorophenyl)ethoxy]-, methyl ester(929040-32-4)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 5-(5-bromo-1H-benzimidazol-1-yl)-3-[(1R)-1-(2-chlorophenyl)ethoxy]-, methyl ester(929040-32-4)

Safety Data

• Hazardous Substances Data: 929040-32-4(Hazardous Substances Data)

Upstream product

• 13524-04-4 (S)-1-(2'-chlorophenyl)ethanol 
• 4887-88-1 5-bromo-1H-benzo[d]imidazole 
• 95201-94-8 methyl 2-chloro-3-oxo-2,3-dihydrothiophen-2-yl-carboxylate 

Downstream Products

• 1140502-18-6 C₂₇H₂₈BClN₂O₅S 

Relevant articles and documents

Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties

Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors' physiochemical and DMPK properties.

5- AND 6- SUBSTITUTED BENZIMIDAZOLE THIOPHENE COMPOUNDS

The present invention provides 5- and 6-substituted benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK MODULATORS

The present invention provides 5-heteroaryl substituted benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES

The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.