929049-50-3

Upstream product

• 929049-49-0 (2R,3S)-3-[N-(2-methoxybenzyl)-N-(2-nitrobenzenesulfonyl)]amino-1-(4-methoxybenzyl)-2-phenylpiperidine 
• 929049-48-9 Methanesulfonic acid (2R,3S)-1-(4-methoxy-benzyl)-2-phenyl-piperidin-3-yl ester 
• 929049-46-7 (5S,6R)-5-hydroxy-1-(4-methoxybenzyl)-6-phenyl-2-piperidinone 
• 929049-47-8 (2R,3S)-3-hydroxy-1-(4-methoxybenzyl)-2-phenyl-piperidine 
• 763106-14-5 (5S,6R)-5-benzyloxy-1-(4-methoxybenzyl)-6-phenyl-2-piperidinone 
• 349099-29-2 (2-methoxybenzyl)(2-nitrobenzenesulfonyl)amine 

Relevant academic research and scientific papers

SN2 reaction of 2-substituted 3-piperidinol mesylate with retention of configuration: application to the asymmetric synthesis of (2R,3S)-CP-99,994

Starting from protected (S)-3-hydroxyglutarimide 2a, the asymmetric synthesis of (2R,3S)-CP-99,994 8 was achieved. The crucial steps were a neighboring group participation leading to pyrrolidino-aziridinium intermediate 25 and the subsequent regioselectiv