929049-52-5

Upstream product

• 763105-90-4 (5S,6R)-5-benzyloxy-1-(4-methoxybenzyl)-6-methyl-2-piperidinone 
• 763105-88-0 (S)-3-benzyloxy-1-(4-methoxybenzyl)-2,6-piperidinedione 
• 562817-53-2 (3S)-1-(4-methoxybenzyl)-3-hydroxypiperidine-2,6-dione 
• 562817-52-1 (S)-N-(4-methoxybenzyl)-tetrahydro-5-oxo-2-furancarboxamide 

Downstream Products

• 929049-53-6 (2R,3S)-3-hydroxy-1-(4-methoxybenzyl)-2-methyl-piperidine 

Relevant academic research and scientific papers

SN2 reaction of 2-substituted 3-piperidinol mesylate with retention of configuration: application to the asymmetric synthesis of (2R,3S)-CP-99,994

Starting from protected (S)-3-hydroxyglutarimide 2a, the asymmetric synthesis of (2R,3S)-CP-99,994 8 was achieved. The crucial steps were a neighboring group participation leading to pyrrolidino-aziridinium intermediate 25 and the subsequent regioselectiv

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regio- and diastereoselective reductive alkylation of (S)-3- benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols.