929088-01-7Relevant articles and documents
Chemically programmed antibodies: Endothelin receptor targeting CovX-Bodies
Doppalapudi, Venkata R.,Tryder, Nancy,Li, Lingna,Aja, Teresa,Griffith, David,Liao, Francesca-Fang,Roxas, Giovanni,Ramprasad, Mysore P.,Bradshaw, Curt,Barbas III, Carlos F.
, p. 501 - 506 (2007/10/03)
Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagonists in vitro and had antitumor efficacy in a prostate cancer xenograft model which, on a molar basis, far exceeded the activity of the parent small molecule.