929099-46-7Relevant academic research and scientific papers
The Hiyama Cross-Coupling Reaction at Parts Per Million Levels of Pd: In Situ Formation of Highly Active Spirosilicates in Glycol Solvents
Ichii, Shun,Hamasaka, Go,Uozumi, Yasuhiro
, p. 3850 - 3854 (2019)
A palladium NNC-pincer complex at a 5 mol ppm loading efficiently catalyzed the Hiyama coupling reaction of aryl bromides with aryl(trialkoxy)silanes in propylene glycol to give the corresponding biaryls in excellent yields. This method was applied to the syntheses of adapalene and a biaryl-type liquid-crystalline compound, as well as to the derivatization of dextromethorphan and norfloxacin. ESI-MS and NMR analyses of the reaction mixture suggested the formation of pentacoordinate spirosilicate intermediates in situ. Preliminary theoretical studies revealed that the glycol-derived silicate intermediates formed in situ are quite reactive silicon reagents in the transmetalation step.
Base- and metal-free C-H direct arylations of naphthalene and other unbiased arenes with diaryliodonium salts
Castro, Susana,Fernandez, Juan J.,Vicente, Ruben,Fananas, Francisco J.,Rodriguez, Felix
supporting information, p. 9089 - 9091 (2012/11/07)
A novel metal-free direct arylation of unbiased arenes with diaryliodonium triflates in a process where the use of solvents and additives is not required has been established.
Gold and palladium combined for cross-coupling
Hashmi, A. Stephen K.,Lothschuetz, Christian,Doepp, Rene,Rudolph, Matthias,Ramamurthi, Tanuja D.,Rominger, Frank
supporting information; experimental part, p. 8243 - 8246 (2010/02/27)
Gold and palladium-a unique liason: A study of the transmetalation abilities of organogold compounds builds the basis for a new class of cross-coupling reactions. Stable intermediates of gold catalysis deliver new complex products by a palladium-catalyzed coupling reaction, (see Scheme)
