929102-01-2Relevant academic research and scientific papers
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
Price, Steve,Bordogna, Walter,Bull, Richard J.,Clark, David E.,Crackett, Peter H.,Dyke, Hazel J.,Gill, Matthew,Harris, Neil V.,Gorski, Julia,Lloyd, Julia,Lockey, Peter M.,Mullett, Julia,Roach, Alan G.,Roussel, Fabien,White, Anne B.
, p. 370 - 375 (2007)
Optimisation of ADS100380, a sub-micromolar HDAC inhibitor identified using a virtual screening approach, led to a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids (6a-i), that possessed significant HDAC inhibitory activity. Subseque
