929105-01-1

Basic information

• Product Name: L-Glutamine, L-threonyl-L-seryl-L-alanyl-L-valyl-L-leucyl-
• CAS NO: 929105-01-1
• Molecular Formula: C26H47N7O10
• Molecular Weight: 617.7
• Mol File: 929105-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Glutamine, L-threonyl-L-seryl-L-alanyl-L-valyl-L-leucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamine, L-threonyl-L-seryl-L-alanyl-L-valyl-L-leucyl-(929105-01-1)
• EPA Substance Registry System: L-Glutamine, L-threonyl-L-seryl-L-alanyl-L-valyl-L-leucyl-(929105-01-1)

Safety Data

• Hazardous Substances Data: 929105-01-1(Hazardous Substances Data)

Upstream product

• 663615-84-7 Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-NH₂ 

Relevant articles and documents

Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant

The 3C-like (3CL) protease of the severe acute respiratory syndrome (SARS) coronavirus is a key enzyme for the virus maturation. We found for the first time that the mature SARS 3CL protease is subject to degradation at 188Arg/189Gln. Replacing Arg with Ile at position 188 rendered the protease resistant to proteolysis. The R188I mutant digested a conserved undecapeptide substrate with a Km of 33.8 μM and kcat of 4753 s-1. Compared with the value reported for the mature protease containing a C-terminal His-tag, the relative activity of the mutant was nearly 106. Novel peptide-aldehyde derivatives containing a side-chain-protected C-terminal Gln efficiently inhibited the catalytic activity of the R188I mutant. The results indicated for the first time that the tetrapeptide sequence is enough for inhibitory activities of peptide-aldehyde derivatives.