929118-49-0

Basic information

• Product Name: Thiazole, 5-bromo-2-[4-(cyclopropylmethoxy)phenoxy]-
• CAS NO: 929118-49-0
• Molecular Formula: C13H12BrNO2S
• Molecular Weight: 326.214
• Mol File: 929118-49-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thiazole, 5-bromo-2-[4-(cyclopropylmethoxy)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 5-bromo-2-[4-(cyclopropylmethoxy)phenoxy]-(929118-49-0)
• EPA Substance Registry System: Thiazole, 5-bromo-2-[4-(cyclopropylmethoxy)phenoxy]-(929118-49-0)

Safety Data

• Hazardous Substances Data: 929118-49-0(Hazardous Substances Data)

Upstream product

• 106-51-4 p-benzoquinone 
• 904961-21-3 4-(5-bromothiazol-2-yloxy)phenol 
• 2516-33-8 Cyclopropylmethanol 

Downstream Products

• 929118-50-3 2-(4-(2-(4-(cyclopropylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)isoindoline-1,3-dione 
• 1384191-46-1 1-{4-[2-(4-cyclopropylmethoxy-phenoxy)-thiazol-5-yloxy]-phenyl}-ethanone 
• 929118-51-4 4-(2-(4-(cyclopropylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-amine 

Relevant articles and documents

NOVEL OLEFIN DERIVATIVE

The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I′): wherein R1 is substituted or unsubstituted aryl etc., R2 is each independently hydrogen, substituted or unsubstituted alkyl etc., R3 is each independently hydrogen, substituted or unsubstituted alkyl etc., n is an integer from 0 to 3, R12 is hydrogen, substituted or unsubstituted alkyl etc., Ring A is aromatic carbocycle or aromatic heterocycle, R9 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., m is an integer from 0 to 4, R4 and R5 is each independently hydrogen, substituted or unsubstituted alkyl etc., R6 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl etc., R13 is hydrogen, substituted or unsubstituted alkyl etc., X5 is bond etc., R7 is hydrogen or substituted or unsubstituted alkyl, R8 is substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl etc.

N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-CoA carboxylase inhibitors - Improvement of cardiovascular and neurological liabilities via structural modifications

A preliminary safety evaluation of ACC2 inhibitor 1-(S) revealed serious neurological and cardiovascular liabilities of this chemotype. A systematic structure-toxicity relationship study identified the alkyne linker as the key motif responsible for these adverse effects. Toxicogenomic studies in rats showed that 1-(R) and 1-(S) induced gene expression patterns similar to that seen with several known cardiotoxic agents such as doxorubicin. Replacement of the alkyne with alternative linker groups led to a new series of ACC inhibitors with drastically improved cardiovascular and neurological profiles.