92916-45-5 Usage
Chemical compound
2-amino-3-((N-2,4,6-trimethylbenzenesulfonyl)indole)propionic acid
Class
Sulfonylindole derivatives
Components
Amino group
Propionic acid group
Sulfonylindole group
2,4,6-trimethylbenzene ring attached
Biological activities
Anti-inflammatory properties
Analgesic properties
Potential medicinal chemistry interest
Pharmacological effects of sulfonylindole moiety
Enhancement of activity with propionic acid group
Research implications
Potential development of novel drugs
Therapeutic potential in treating various diseases
Check Digit Verification of cas no
The CAS Registry Mumber 92916-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,9,1 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 92916-45:
(7*9)+(6*2)+(5*9)+(4*1)+(3*6)+(2*4)+(1*5)=155
155 % 10 = 5
So 92916-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N2O4S/c1-12-8-13(2)19(14(3)9-12)27(25,26)22-11-15(10-17(21)20(23)24)16-6-4-5-7-18(16)22/h4-9,11,17H,10,21H2,1-3H3,(H,23,24)/t17-/m0/s1
92916-45-5Relevant academic research and scientific papers
Acceleration of the N(α)-deprotection rate by the addition of m-cresol to diluted methanesulfonic acid and its application to the Z(OMe)-based solid-phase syntheses of human pancreastatin-29 and magainin 1
Tamamura,Nakamura,Noguchi,Funakoshi,Fujii
, p. 954 - 957 (2007/10/02)
In solid-phase peptide synthesis, the addition of m-cresol to diluted methanesulfonic acid (MSA) in dichloromethane accelerated the deprotection rate of the acid-labile α-amino protecting group, the p-methoxybenzyloxycarbonyl (Z(OMe)) group. Further, 0.1 M MSA, 20% m-cresol/CH2Cl2 was found to be a practically useful N(α)-deprotecting reagent system, since the deprotection of the Z(OMe) group occurred selectively within 30 min at room temperature, leaving intact the other side chain protecting groups, such as benzyloxycarbonyl, benzyl ester, S-p-methoxybenzyl and N(G)-mesitylene-2-sulfonyl groups. This reagent system was applied to the Z(OMe)-based solid phase syntheses of human pancreastatin-29 and magainin 1.
