92919-46-5

Upstream product

• 21815-91-8 3-chlorobenzo[b]thiophen-2-carbonyl chloride 
• 62-53-3 aniline 
• 1147550-11-5 ammonium thiocyanate 
• 621-82-9 Cinnamic acid 
• 16503-53-0 2-bromo-3-phenylpropanoic acid 
• 88439-43-4 3-chloro-2-isothiocyanatocarbonylbenzothiophene 

Downstream Products

• 92919-50-1 2-Phenylamino-4H-<1>-benzothieno<2,3-e>-1,3-thiazin-4-on 
• 21211-09-6 3-chlorobenzo-[b]thiophene-2-carboxamide 
• 102-08-9 N,N-diphenylthiourea 
• 872680-15-4 C₁₈H₁₁ClN₂O₂S₂ 
• 1268872-46-3 C₁₉H₁₁ClN₂O₃S₂ 

Relevant academic research and scientific papers

Synthesis and biological activities of some new thiazolidine-4-ones and pyrimidines incorporating benzo (b) thiophene

Thiazolidine-4-ones and pyrimidines incorporating benzo (o) thiophene have been prepared starting from 3-chlorobenzo(6) thiophen-2-carbonyl chloride. All the newly synthesized compounds were characterized by elemental analysis, IR 1H NMR and ma

Synthesis of heterocycles from the products of anionic arylation of unsaturated compounds. 7*. Products of haloarylation of acrylic acid and its esters in the synthesis of benzo[b]thiophene derivatives

3-Chloro-2-chlorocarbonylbenzo[b]thiophenes were obtained on oxidation of Meerwein reaction products, viz. 3-aryl-2-halopropionic acids and their esters, with thionyl chloride in the presence of N-benzyl-N-methylmorpholinium chloride. Disubstituted thioureas were synthesized by the reaction of these compounds with ammonium thiocyanate and aromatic amines, and were cyclized by interaction with iodoacetic acid with the formation of 4-thiazolidinone derivatives. The same cyclization in the presence of aromatic aldehydes leads to the formation of the corresponding 5-arylidene-substituted 4-thiazolidinones.

PHOTOCYCLIZATION OF N-(3-CHLORO-2-BENZOTHIENOCARBONYL)-N'-MONOSUBSTITUTED THIOUREAS

N-(3-chloro-2-benzothienocarbonyl)-N'-monosubstituted thioureas, when irradiated with a high-pressure mercury discharge lamp through a pyrex or quartz filter, give the corresponding benzothienothiazine derivatives in lower yields than the analogous N',

Synthesis and Reaction Behaviour of N-(3-Chlorobenzothiophene-2-carbonyl)imino-dithiocarbonic Derivatives

3-Chlorobenzothiophene-2-carbonyl-chloride 1 was treated with potassium rhodanide to afford the appropiate acyl isothiocyanate 3, which adds nucleophilic agents as amines and thioles in good yields.Addition of methanethiole and subsequent alkylation of the dithiocarbamate 7 gives S,S-dimethyl-imino-dithiocarbonate 8. 3-Chlorobenzothiophene-2-carboxamide 2 reacts with carbon disulphide and phenyl isothiocyanate by chlorine substitution and cyclisation to benzothienothiazines 9, 10 or 11.The structure of the final products were determined by analytical and spectroscopical dates.