92950-41-9Relevant academic research and scientific papers
Organocatalytic site-selective acylation of 10-deacetylbaccatin III
Yanagi, Masanori,Ninomiya, Ryo,Ueda, Yoshihiro,Furuta, Takumi,Yamada, Takeshi,Sunazuka, Toshiaki,Kawabata, Takeo
, p. 907 - 912 (2016/07/14)
Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.
CHEMICAL STUDIES OF 10-DEACETYL BACCATIN III. HEMISYNTHESIS OF TAXOL DERIVATIVES.
Gueritte-Voegelein, F.,Senilh, V.,David, B.,Guenard, B.,Potier, P.
, p. 4451 - 4460 (2007/10/02)
The chemical reactivities of 10-deacetyl baccatin III and of baccatin III, two natural products extracted from Taxus baccata L., were studied with aim of synthesizing taxol analogues having a modified side-chain at C-13, thereby restoring good binding to tubulin.
