92952-84-6

Basic information

• Product Name: N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB005584;N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE;1-(2-CHLOROETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;1-(2-CHLOROETHYL)IMIDAZOLE HYDROCHLORIDE;N-(2-chloroethyl)-imidazoleHCl
• CAS NO: 92952-84-6
• Molecular Formula: C₅H₇ClN₂
• Molecular Weight: 167.04
• Mol File: 92952-84-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 108-118°C
• Boiling Point: 269.9°Cat760mmHg
• Flash Point: 117°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.0117mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE(92952-84-6)
• EPA Substance Registry System: N-(2-CHLOROETHYL)-IMIDAZOLE HYDROCHLORIDE(92952-84-6)

Safety Data

• Hazardous Substances Data: 92952-84-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H7ClN2/c6-1-3-8-4-2-7-5-8/h2,4-5H,1,3H2

Upstream product

• 288-32-4 1H-imidazole 
• 107-06-2 1,2-dichloro-ethane 
• 107-04-0 1-Bromo-2-chloroethane 
• 1615-14-1 1-(2-Hydroxyethyl)imidazole 
• 5587-42-8 imidazolyl sodium 

Downstream Products

• 1072-63-5 1-vinylimidazole 
• 302963-89-9 N-(2-chloro-6-methylphenyl)-2-[[4-[2-(1H-imidazol-1-yl)ethoxy]-3-methoxyphenyl]amino]-5-thiazolecarboxamide 
• 1178564-42-5 3-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione 
• 1421770-29-7 1-(2-(phenylselanyl)ethyl)-1H-imidazole 
• 62037-81-4 2-(1H-imidazol-1-yl)ethyl methacrylate 
• 1178894-58-0 3-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione 

Relevant articles and documents

The first bridged, bifunctional cyclopentadienyl-imidazolylidene ligand and complexes with titanium and zirconium

Starting from imidazole, l-[2-(cyclopenta-2,4-dienyl)ethyl]-3- methylimidazolium iodide (3) was obtained as a mixture of isomers by a simple three-step synthesis. The reaction of 3 with Ti(NEt2)4 or Zr(NEt2)4 by double deprotonation of the imidazolium salt led to the isomerically pure cationic complexes [{η5-C 5H4-(CH2)2-NHC}M(NEt 2)2]+I- (NHC = N-heterocyclic carbene) 4a (M = Ti) and 4b (M = Zr), respectively, in which a cyclopentadienyl and a methylimidazol-2-ylidene unit are linked by an ethylidene-1,2 bridge to form a novel chelating ligand system. In the case of the reaction of 3 with Zr(NEt2)4 the neutral compound [{η5-C 5H4-(CH2)2-NHC}Zr(NEt 2)I2] (5) is formed as an additional product. According to the X-ray structure analyses, the titanium atom of 4a is terracoordinated while no coordinative interaction exists with the iodide anion; on the other hand, in 5 the zirconium centre is pentacoordinated.

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Controlled introduction of metal cations into polymerizable ionic liquid-polyoxomolybdate hybrid crystals

A polymerizable ionic-liquid cation having methacryl group and imidazolium moieties (denoted as MAImC1) was successfully hybridized with octamolybdate (Mo8O264?, Mo8) to obtain inorganic-organic hybrid crystals containing monovalent metal cations. The hybrid crystals were initially prepared as sodium ion-containing hybrid crystal of MAImC1-Na-Mo8. The sodium cations in MAImC1-Na-Mo8 were exchangeable to other monovalent metal cations such as silver or potassium to form hybrid crystals of MAImC1-Ag-Mo8 or MAImC1-K-Mo8. Their molecular and crystal structures were clearly revealed by single crystal X-ray analyses. The MAImC1-Na-Mo8 hybrid crystal worked as the hybrid monomer, and was found polymerizable by a radical polymerization using AIBN as an initiator to obtain inorganic-organic polymers (P-MAImC1-Na-Mo8). The conductivities of the hybrid monomer and polymer consisting of MAImC1-Na-Mo8 were investigated.