92956-89-3Relevant academic research and scientific papers
Alkynylation of aldehydes mediated by zinc and allyl bromide: a practical synthesis of propargylic alcohols
Zhou, Ji-Cai,Zhao, Lei,Li, Yuan,Fu, Ding-Qiang,Li, Zi-Cheng,Huang, Wen-Cai
, p. 4283 - 4294 (2017/06/20)
Abstract: A practical synthesis of propargylic alcohols was developed by alkynylation of aldehydes mediated by zinc and allyl bromide. Aromatic, aliphatic and vinyl aldehydes react with phenylacetylene or 1-hexyne to obtain various propargylic alcohols at room temperature in up to 98% yield. This method is characterized with inexpensive materials, wide substrate scope, and mild reaction conditions, and is also easy to scale up. In addition, this protocol is applicable to the alkynylation of α-ketone esters and epoxides to generate α-tertiary-hydroxy esters and α-alkynyl alcohols, respectively. Graphical Abstract: [Figure not available: see fulltext.].
Acid-mediated synthesis of fully substituted 1,2,3-triazoles: Multicomponent coupling reactions, mechanistic study, synthesis of serine hydrolase inhibitor and its derivatives
Zhang, Huan,Tanimoto, Hiroki,Morimoto, Tsumoru,Nishiyama, Yasuhiro,Kakiuchi, Kiyomi
, p. 9828 - 9835 (2015/01/09)
We describe the full details of multicomponent coupling reactions in acid-mediated synthesis of fully substituted 1,2,3-triazoles syntheses, and their applications to bioactive molecule synthesis. For substitution with wide range of nucleophiles, selectio
Bifunctionalized allenes, Part IX: An efficient method for regioselective synthesis of 4-heteroatom-functionalized allenecarboxylates
Ivanov, Ivaylo K.,Parushev, Ivaylo D.,Christov, Valerij Ch.
, p. 322 - 331 (2013/08/15)
An efficient method for regioselective synthesis of 4-heteroatom- functionalized allenecarboxylates by an atom economical [2,3]-sigmatropic rearrangement of the mediated 2-heteroatom-functionalized alk-3-ynecarboxylates is described. Alkyl 4-(dimethoxypho
