92959-60-9Relevant academic research and scientific papers
Design, synthesis, and antitumor screening of certain novel tetrahydroquinoline sulfonamides
Alafeefy, Ahmed M.
, p. 189 - 194 (2015/04/14)
Sulfonamide containing molecules are of sound biomedical interest. This work comprises the synthesis and in vitro antitumor testing of new library of 20 such molecules. These compounds were screened for cytotoxic activity against three tumor cell lines MC
In vitro cytotoxic evaluation of some new heterocyclic sulfonamide derivatives
Ghorab, Mostafa M.,Al-Said, Mansour S.,El-Hossary, Ebaa M.
experimental part, p. 563 - 571 (2011/07/30)
Sulfonamide-bearing compounds posses many types of biological activities and have been recently reported to show substantial antitumor activity in vitro and/or in vivo. There are a variety of mechanisms for the anticancer activity, and the most prominent
Discovering some novel tetrahydroquinoline derivatives bearing the biologically active sulfonamide moiety as a new class of antitumor agents
Alqasoumi, Saleh I.,Al-Taweel, Areej M.,Alafeefy, Ahmed M.,Ghorab, Mostafa M.,Noaman, Eman
experimental part, p. 1849 - 1853 (2010/06/17)
The present article describes the synthesis of some novel 4-(2-amino-3-cyano-4-(substituted-aryl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl)benzenesulfonamide (23-41) starting with 4-(3-oxo-cyclohex-1-enylamino)benzenesulfonamide (3). All the newly synthesized compounds were evaluated for their in vitro antitumor activity. Compounds 32, 25, 41, 35, 33, and 37 with IC50 values (2.5, 3, 5, 10, 12, and 12.5 μg/mL) are more potent and efficacious than Doxorubicin (CAS-23214-92-8) as reference drug with (IC50 value = 37.5 μg/mL). Also, compounds 28, 30, 31, and 34 (with IC50 values = 25 μg/mL) are nearly as active as Doxorubicin.
Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
Alqasoumi, Saleh I.,Al-Taweel, Areej M.,Alafeefy, Ahmed M.,Noaman, Eman,Ghorab, Mostafa M.
experimental part, p. 738 - 744 (2010/04/04)
Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24, 19 and 12 showed higher activity with IC50 values (5.5, 6.9, 7 μg/ml) when compared with Doxorubicin as a reference drug (IC50 value 38 μg/ml).
