929611-05-2Relevant academic research and scientific papers
MCH-R1 antagonists based on an arginine scaffold: SAR studies on the amino-terminus
Mendez-Andino, Jose,Colson, Anny-Odile,Denton, Daniel,Mitchell, Maria C.,Cross-Doersen, Doreen,Hu, X. Eric
, p. 832 - 835 (2007/10/03)
We have identified a novel series of potent MCH-R1 antagonists based on l-arginine. As predicted by computational methods, there was an activity dependence on the π-electronic character of the aromatic systems corresponding to the amino-terminus of these molecules. These results have enhanced our understanding of the MCH-R1 receptor and the potential for a predictive homology model.
