929612-78-2

Upstream product

• 220239-67-8 2-[2-(trifluoromethoxy)phenyl]acetic acid 

Downstream Products

• 509143-10-6 N-[4-(4-dimethylamino-quinazolin-2-ylamino)-cyclohexylmethyl]-2-(2-trifluoromethoxy-phenyl)-acetamide 
• 929611-97-2 3-(2-trifluoromethoxybenzyl)-5-(3-trifluoromethylphenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one 
• 929612-04-4 3-(3-trifluoromethoxybenzyl)-5-(3-trifluoromethoxyphenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one 
• 929612-03-3 3-(2-trifluoromethoxybenzyl)-5-(3-trifluoromethoxyphenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one 
• 929611-81-4 5-phenyl-3-(2-trifluoromethoxybenzyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one 
• 929612-50-0 4-Hydroxy-1-(3-trifluoromethoxyphenyl)-3-(2-trifluoromethoxyphenylacetyl)-1,8-naphthyridin-2(1H)-one 
• 929612-44-2 4-hydroxy-3-(2-trifluoromethoxyphenylacetyl)-1-(3-trifluoromethylphenyl)-1,8-naphthyridine-2(1H)-one 

Relevant academic research and scientific papers

Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists

The optimization of the distance between two key pharmacophore features within our first hit compounds 1a and 2a led to the identification of a new class of potent non-peptidic antagonists for the MCH-R1, based around 4-amino-2-cyclohexylaminoquinazolines. In particular, ATC0065 (2c), N2-[cis-4-({2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl}amino)cyclohexyl]-N4,N4-dimethylquinazoline-2,4-diamine dihydrochloride, bound with high affinity to the MCH-R1 (IC50 value of 16 nM) and showed good metabolic stability in liver microsomes from human and rat.