929613-76-3

Upstream product

• 7460-55-1 2-(2-bromoacetyl)benzoic acid methyl ester 
• 1077-79-8 methyl 2-acetylbenzoate 
• 577-56-0 2-acetyl-benzoic acid 
• 85-44-9 phthalic anhydride 
• 929613-61-6 methyl 2-(2-(3,4-difluorophenylthio)acetyl)benzoate 
• 929613-63-8 1-hydroxy-4-(3,4-difluorophenyl)thiomethylphthalazine 

Downstream Products

• 929613-69-4 1-(4-fluoro-3-trifluoromethylanilino)-4-(3,4-difluorophenylthiomethyl)phthalazine 
• 929613-70-7 1-(3,5-dichloroanilino)-4-(3,4-difluorophenylthiomethyl)phthalazine 

Relevant academic research and scientific papers

Synthesis and anticancer activities of novel 1,4-disubstituted phthalazines

A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4-difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4-(3,4-difluorophenyl-thiomethyl) phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method.