929617-25-4 Usage
Molecular weight
290.73 g/mol The molecular weight is the mass of one mole of the compound, calculated by adding the atomic weights of all the atoms in the molecular formula.
Structure
1H-Pyrazolo[3,4-c]pyridine core with a 5-chloro substitution and a 1,1-dimethylethyl ester group The compound consists of a pyrazolopyridine ring system with a chlorine atom at the 5-position and a tert-butoxycarbonyl (Boc) group esterified to the carboxylic acid.
Heterocyclic compound
Derived from pyrazolopyridine The compound is a derivative of pyrazolopyridine, which is a type of heterocyclic compound containing both pyrazole and pyridine rings.
Bioactivity
Potential bioactivity due to the 5-chloro substitution The presence of the chlorine atom on the pyrazolopyridine ring may provide the compound with potential bioactivity, making it a candidate for pharmaceutical applications.
Protecting group
Tert-butoxycarbonyl (Boc) group on the carboxylic acid The Boc group serves as a protecting group for the carboxylic acid functional group, allowing for selective manipulation of amino acid side chains during peptide synthesis.
Application
Building block in the synthesis of bioactive molecules or as a potential drug candidate The compound can be used as a building block for synthesizing other bioactive molecules or as a potential drug candidate in medicinal chemistry research.
Check Digit Verification of cas no
The CAS Registry Mumber 929617-25-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,6,1 and 7 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 929617-25:
(8*9)+(7*2)+(6*9)+(5*6)+(4*1)+(3*7)+(2*2)+(1*5)=204
204 % 10 = 4
So 929617-25-4 is a valid CAS Registry Number.
929617-25-4Relevant academic research and scientific papers
Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Woods, Keith,Luo, Yan,Liu, Xuesong,Guan, Ran,Klinghofer, Vered,Johnson, Eric F.,Stoll, Vincent S.,Mamo, Mulugeta,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2441 - 2452 (2007)
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.
