929686-79-3Relevant academic research and scientific papers
Supported TBD-assisted solution phase diversification of formyl-aza-heterocycles through alkylation-knoevenagel one pot sequences
Maatougui, Abdelaziz El,Crespo, Abel,Silva, Artur M.S.,Coelho, Alberto
, p. 570 - 582 (2012/07/31)
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.
Efficient consecutive alkylation-Knoevenagel functionalisations in formyl aza-heterocycles using supported organic bases
Coelho, Alberto,El-Maatougui, Abdelaziz,Ravi?a, Enrique,Cavaleiro, José A. S.,Silva, Artur M. S.
, p. 3324 - 3328 (2008/09/17)
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl aza-heterocycles employing supported organic bases (PS-BEMP, PS-TBD or Si-TBD) is described. The library synthesis is based on a consecutive alkylation-Knoevenagel functionalisation that employs alkyl halides, Michael acceptors, and malonic acid derivatives as diversity elements. Georg Thieme Verlag Stuttgart.
