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5-phenyl-4-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol is a complex organic compound with the molecular formula C14H10N4S. It is a derivative of 1,2,4-triazole, a five-membered heterocyclic ring containing three nitrogen atoms and one sulfur atom. The compound features a phenyl group attached to the 5-position and a pyridin-3-yl group at the 4-position of the triazole ring. This specific arrangement of functional groups endows the molecule with unique chemical and physical properties, making it potentially useful in various applications, such as pharmaceuticals, agrochemicals, or materials science. Due to its complex structure, the compound may exhibit specific reactivity and stability, which can be further explored for its potential applications in different fields.

929826-32-4

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929826-32-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 929826-32-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,8,2 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 929826-32:
(8*9)+(7*2)+(6*9)+(5*8)+(4*2)+(3*6)+(2*3)+(1*2)=214
214 % 10 = 4
So 929826-32-4 is a valid CAS Registry Number.

929826-32-4Downstream Products

929826-32-4Relevant articles and documents

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification

Peng, Kewen,Li, Yu,Bai, Ying,Jiang, Teng,Sun, Huiyong,Zhu, Qihua,Xu, Yungen

, (2019/11/29)

Multifaceted roles of vascular endothelial growth factor (VEGF)-neuropilin-1 (NRP1) interaction have been implicated in cancer, but reports on small-molecule inhibitors of VEGF-NRP1 interaction are scarce. Herein, we describe the identification of 1, a novel nonpeptide small-molecule NRP1 antagonist with moderate activity via structure-based virtual screening. Ensemble docking and molecular dynamics (MD) simulations of 1 were carried out and an interesting binding model was obtained. We found that the “aromatic box” enclosed by Tyr297, Trp301 and Tyr353 of NRP1 is critical for NRP1-1 binding. Further structure modification of 1 based on the binding model derived from MD simulations resulted in the identification of 12a with significantly improved activity.

THIOTRIAZOLYL DERIVATIVES

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Page/Page column 68, (2008/06/13)

The invention relates to KvI.5 ion channel antagonists. Novel thiotriazolyl derivative compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by KvI.5 ion channels, are disclosed. Such cond

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