929917-65-7Relevant academic research and scientific papers
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography
Davies, Douglas R.,Mamat, Bjorn,Magnusson, Olafur T.,Christensen, Jeff,Haraldsson, Magnus H.,Mishra, Rama,Pease, Brian,Hansen, Erik,Singh, Jasbir,Zembower, David,Kim, Hidong,Kiselyov, Alex S.,Burgin, Alex B.,Gurney, Mark E.,Stewart, Lance J.
experimental part, p. 4694 - 4715 (2010/03/02)
We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facili
BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
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Page/Page column 39, (2008/06/13)
The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is
