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Usage

Uses

Used in Pharmaceutical and Agricultural Chemicals Synthesis:
2-Methoxy-4-pyridinecarbothioamide is used as an intermediate in the synthesis of various pharmaceutical and agricultural chemicals. Its unique chemical structure allows for the creation of a wide range of compounds with diverse applications in these industries.
Used in Organic Chemistry Reactions:
In the realm of organic chemistry, 2-Methoxy-4-pyridinecarbothioamide is employed as a reagent to introduce the pyridinecarbothioamide functional group into organic molecules. This contributes to the development of new organic compounds with specific properties and potential applications.
Used in Antifungal Applications:
2-Methoxy-4-pyridinecarbothioamide is used as an antifungal agent, leveraging its potential biological activities to combat fungal infections. Its effectiveness in this application can be attributed to its ability to interfere with essential fungal processes, thereby inhibiting their growth and proliferation.
Used in Antimicrobial Applications:
Similarly, 2-Methoxy-4-pyridinecarbothioamide is utilized in antimicrobial applications, where it exhibits properties that can inhibit the growth of various microorganisms. This makes it a promising candidate for use in the development of new antimicrobial agents to address the growing concerns of antibiotic resistance.

Upstream product

• 72716-86-0 4-cyano-2-methoxypyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 1527-89-5 3-methoxybenzonitrile 

Relevant academic research and scientific papers

Diarylthiazole: An antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize the potency and physicochemical properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochemical properties. The potent antimycobacterial activity, in conjunction with low molecular weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational analysis showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.

Pyrid-2-one derivatives and methods of use

Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.