930-83-6Relevant academic research and scientific papers
Indole-2,3-dione-3-oxime derivatives for therapeutic use
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, (2008/06/13)
The present invention relates to the use of indole-2,3-dione-3-oxime derivatives in a method of combating diseases and disorders associated with or mediated by the release of excitatory amino acids.
Indole-2,3-dione-3-oxime derivatives
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, (2008/06/13)
PCT No. PCT/DK97/00418 Sec. 371 Date Jun. 1, 1998 Sec. 102(e) Date Jun. 1, 1998 PCT Filed Oct. 1, 1997 PCT Pub. No. WO98/14447 PCT Pub. Date Apr. 9, 1998The present invention relates to novel indole-2,3-dione-3-oxime derivatives capable of antagonising th
Synthesis of 3-Hydroxyisoxazoles from β-Ketoesters and Hydroxylamine
Sato, Kazuo,Sugai, Soji,Tomita, Kazuo
, p. 1831 - 1838 (2007/10/02)
An efficient synthesis of 3-hydroxyisoxazoles from β-ketoesters and hydroxylamine was investigated.The reaction of the sodium salts of β-ketoesters and hydroxylamine at a low temperature, followed by quenching with an excess of conc.HCl under heating gave predominantly 3-hydroxyisoxazoles involving 4-sulfenylated 3-hydroxyisoxazoles.Starting from the prepared 4-(2,4-dichlorobenzyl)-3-hydroxy-5-methylisoxazole, a potential herbicidal compound, 4-(2,4-dichlorobenzoyl)-3-hydroxy-5-methylisoxazole, was also synthesized in five steps.
