930089-08-0Relevant academic research and scientific papers
Synthesis, solution thermodynamics, and X-ray study of CuII [12]metallacrown-4 with GABA hydroxamic acid: An unprecedented crystal structure of a [12]MC-4 with a γ-aminohydroxamate
Tegoni, Matteo,Ferretti, Luca,Sansone, Francesco,Remelli, Maurizio,Bertolasi, Valerio,Dallavalle, Francesco
, p. 1300 - 1308 (2007)
The solution equilibria of γ-aminobutanehydroxamic acid (GABAha) with H+ and Cu2+ were investigated by potentiometry, titration calorimetry, spectrophotometry, NMR spectroscopy, and ESI-MS. The thermodynamic parameters of the CuII [12]metallacrown-4 obtained for GABAha were compared with those of the corresponding complexes of (S)-α-Alaha and β-Alaha. The stability (-ΔG0) sequence was β-Alahaa ? α-Alaha > GABAha, whereas the order of formation enthalpies (-ΔH0) was β-Alaha ? GABAha > α-Alaha. These data were interpreted on the basis of the dimensions of the chelate rings and the planarity of the metallamacrocycles. The CuII [12]metallacrown-4 ([12]MC-4) complex of GABAha was isolated and its crystal structure, which is the first reported for a [12]MC-4 of a γ-aminohydroxamic acid, fully supports the structural features interpreted from the thermodynamic data.
