930117-91-2

Upstream product

• 930117-90-1 C₂₀H₂₈N₂O₃ 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 930117-92-3 (Z)-2-N-BOC-amino-3-(4-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]-methyl}phenyl)propenoic acid 

Relevant academic research and scientific papers

PROCESS TO PREPARE AMINO ACID DERIVATIVES

The present invention comprises a novel multi-step process to a specific amino acid derivative (1) from (4-hydroxymethyl)benzaldehyde including the key steps of: (i) asymmetric hydrogenation, thereby avoiding yield losses associated with the resolution approach and (ii) introduction of the cis-2,6-dimethylpiperidine sub-unit by JV-alkylation, thereby avoiding a problematic reductive animation step that is prone to side reactions. In one aspect, the present invention comprises a synthetic route in which step (i) precedes step (ii). In another aspect of the invention, step (ii) precedes step (i) (I).