93019-52-4Relevant articles and documents
Asymmetric synthesis of vabicaserin via oxidative multicomponent annulation and asymmetric hydrogenation of a 3,4-substituted quinolinium salt
Dragan, Vladimir,McWilliams, J. Christopher,Miller, Ross,Sutherland, Karen,Dillon, John L.,O'Brien, Michael K.
, p. 2942 - 2945 (2013)
An efficient, asymmetric synthesis of the 5-HT2C agonist vabicaserin in four chemical steps and 54% overall yield from commercially available benzodiazepine was achieved. The synthesis was highlighted by a novel oxidative, multicomponent reaction to affect the quinolinium ring assembly in one step followed by an unprecedented asymmetric hydrogenation of a 3,4-substituted quinolinium salt.