930269-91-3Relevant academic research and scientific papers
Cation-π control of regiochemistry of intramolecular Schmidt reactions en route to bridged bicyclic lactams
Yao, Lei,Aube, Jeffrey
, p. 2766 - 2767 (2007)
The regiochemistry of the intramolecular Schmidt reaction of 2-substituted ketones has proved susceptible to control by the placement of an aromatic group at an adjacent position, permitting the selective formation of a series of bridged bicyclic lactams
In situ generation and intramolecular schmidt reaction of keto azides in a microwave-assisted flow format
Painter, Thomas O.,Thornton, Paul D.,Orestano, Mario,Santini, Conrad,Organ, Michael G.,Aube, Jeffrey
supporting information; experimental part, p. 9595 - 9598 (2011/10/04)
Go with the flow! A method for conversion of keto halides to lactams by means of sequential azidation and intramolecular Schmidt reaction in a combined flow format is described (see scheme; MWI=microwave irradiation, TFA=trifluoroacetic acid).
Synthesis of medium-bridged twisted lactams via cation-π control of the regiochemistry of the intramolecular Schmidt reaction
Szostak, Michal,Yao, Lei,Aube, Jeffrey
supporting information; experimental part, p. 1235 - 1243 (2010/04/26)
(Chemical Equation Presented) Medium-bridged twisted amides can be synthesized by the intramolecular Schmidt reaction of 2-azidoalkyl ketones. In these reactions, the regiochemistry of the Schmidt reaction is diverted into a typically disfavored pathway b
