930284-53-0

Upstream product

• 61973-87-3 tetraethyl 2,6-bis(methanephosphonate)pyridine 
• 205187-83-3 4,4-N,N'-dimethylamino-3-methoxybenzaldehyde 
• 7703-74-4 2,6-bis-(bromomethyl)pyridine 

Relevant academic research and scientific papers

COMPOUND FOR INHIBITING THE FORMATION OF BETA-AMYLOID FIBRIL, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel compound which is effective in inhibiting the formation of beta-amyloid fibril in the brain, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.

Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation

New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Aβ fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activ