930292-90-3Relevant academic research and scientific papers
Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonit rile PKCθ inhibitors
Wu, Biqi,Boschelli, Diane H.,Lee, Julie,Yang, Xiaoke,Chaudhary, Divya
scheme or table, p. 766 - 769 (2009/08/07)
Thieno[2,3-b]pyridine-5-carbonitrile 16 with a 4-methyl-5-indolylamine at C-4 and a 5-methoxy-2-(dimethylamino)-methylphenyl group at C-2 had an IC50 value of 16 nM for the inhibition of PKCθ. While moderate inhibition of PKCδ was also observed
Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors
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Page/Page column 57-58, (2010/11/26)
Disclosed are compounds of Formula I: wherein R1, R2, R3, R4, and X, are defined hereinbefore in the specification, which can be useful in the treatment of autoimmune and inflammatory diseases, and processes for producing said compounds.
