930292-97-0Relevant academic research and scientific papers
Synthesis and PKCθ inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles
Boschelli, Diane H.,Wu, Biqi,Barrios Sosa, Ana Carolina,Chen, Joan,Asselin, Magda,Cole, Derek C.,Lee, Julie,Yang, Xiaoke,Chaudhary, Divya
, p. 2850 - 2853 (2008/12/22)
The thieno[2,3-b]pyridine-5-carbonitrile with a 5-indolylamine at C-4 and a phenyl group at C-2 had a moderate activity against PKCθ. Optimization of the groups at C-4 and C-2 led to analog 29, which has an IC50 value of 7.5 nM for the inhibition of PKCθ.
Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles
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Page/Page column 18, (2008/06/13)
A process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles, which can be useful for the preparation of protein kinase inhibitors, is provided.
