930293-15-5

Usage

Uses

Used in Pharmaceutical Synthesis:
4-chloro-2-iodo-3-Methylthieno[2,3-b]pyridine-5-carbonitrile is used as an intermediate in the synthesis of pharmaceuticals due to its potential biological activity. Its unique structure allows for the development of new drugs with specific therapeutic effects.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-chloro-2-iodo-3-Methylthieno[2,3-b]pyridine-5-carbonitrile is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the creation of compounds with targeted effects on pests or weeds.
Safety Considerations:
When working with 4-chloro-2-iodo-3-Methylthieno[2,3-b]pyridine-5-carbonitrile in a laboratory setting, it is crucial to handle the compound with care and adhere to proper safety protocols. This includes using appropriate personal protective equipment, working in a well-ventilated area, and following guidelines for chemical storage and disposal.

Upstream product

• 1092655-83-8 C₉H₅IN₂OS 

Relevant academic research and scientific papers

2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ

A series of 2-alkenyl thieno[2,3-b]pyridine inhibitors of PKCθ were synthesized as potential inflammatory modulators. This series led to the discovery of 2-alkenyl amides, which are exceptionally potent and selective inhibitors of PKCθ. Compound 8 has an IC50 of 3.8 nM against PKCθ and shows excellent selectivity over a variety of PKC isoforms.

A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles

We report a new synthesis of thieno[2,3-b]pyridine-5-carbonitriles from 2-aminothiophene-3-carboxylate esters. The key step of the synthesis is a thermally promoted elimination/decarboxylation followed by nucleophilic cyclization to give 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles. The reactions proceed in good yield and generally require no chromatographic purification. These compounds are easily transformed in two steps to 4-chloro-2-iodothieno[2,3-b]pyridine-5-carbonitriles which are key intermediates in the synthesis of various kinase inhibitors.

Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles

A process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles, which can be useful for the preparation of protein kinase inhibitors, is provided.