930577-39-2

Upstream product

• 1292822-16-2 (S)-3-[(4-methoxybenzyl)thio]-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide 
• 1292822-17-3 (S)-3-mercapto-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide 
• 74-88-4 methyl iodide 
• 3789-59-1 (R)-1-phenylpropylamine 

Downstream Products

• 930577-40-5 3-methylsulfinyl-2-phenyl-N-((S)-1-phenylpropyl)-quinoline-4-carboxamide 
• 1061198-04-6 C₂₆H₂₄N₂O₂S 
• 1061198-02-4 C₂₆H₂₄N₂O₂S 

Relevant academic research and scientific papers

Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists

The neurokinin-3 (NK3) receptor is regarded as a potential novel target for treating patients with schizophrenia. Herein we report the synthesis and SAR of a series of C3-alkylsulfoxide substituted quinolines as potent NK3 receptor antagonists. These compounds have excellent NK3 functional activity, good selectivity and drug-like properties. Several key compounds have good in vitro/in vivo DMPK characteristics, and are active in a gerbil locomotor activity model.

QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE IN TREATING CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES

Compounds of Formula (I) wherein R1, R2, n and R3 are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.