93074-02-3

Basic information

• Product Name: 5-ketomilbemycin D 5-oxime
• CAS NO: 93074-02-3
• Molecular Weight: 569.739
• Mol File: 93074-02-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 760.3±60.0 °C(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 5-ketomilbemycin D 5-oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ketomilbemycin D 5-oxime(93074-02-3)
• EPA Substance Registry System: 5-ketomilbemycin D 5-oxime(93074-02-3)

Safety Data

• Hazardous Substances Data: 93074-02-3(Hazardous Substances Data)

Usage

Uses

5-Ketomilbemycin D 5-Oxime is an impurity of Milbemycin Oxime (M344280), which is antiparasitic used in veterinary medicine. Also related to Abamectin >80% (A107000).

Upstream product

• 77855-81-3 milbemycin D 
• 87616-38-4 5-oxo-5-deoxymilbemycin D 

Relevant articles and documents

Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae.

Starting from milbemycin D (1), milbemycin A4 (2) and milbemycin A3 (3), a series of 5-keto-5-oxime derivatives were synthesized by selective oximation at the alpha,beta-conjugated carbonyl function of the 5-ketomilbemycins (4-6). The activities of the synthesized compounds were studied in dogs naturally infested with microfilariae of Dirofilaria immitis. The 5-keto-5-oximes of milbemycin D (7), A4 (8) and A3 (9) had quite high efficacy to control the microfilariae and more potency than their parents, while the 5-O-acyl oximes (11-15) also exhibited high activity.