930768-35-7

Upstream product

• 80370-42-9 ethyl 2-formyl-3-oxopropanoate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 37622-90-5 4-ethoxycarbonylpyrazole 
• 98-59-9 p-toluenesulfonyl chloride 
• 4124-41-8 p-toluenesulfonylanhydride 

Downstream Products

• 1219601-44-1 C₁₇H₁₅N₃O₂ 
• 1219601-52-1 C₁₃H₁₆N₄O₂ 
• 1219601-29-2 C₁₄H₁₆N₂O₃S 
• 930768-36-8 (1-tosyl-1H-pyrazol-4-yl)methanol 

Relevant academic research and scientific papers

One-step conversion of azine N -oxides to α-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes

Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were converted to their α-triazole and α-diazole derivatives by treatment with the corresponding p-toluenesulfonylazoles and Hunigs base at elevated temperatures.

AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS

Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

ARYL SUBSTITUTED IMIDAZO [4,5-C] PYRIDINE COMPOUNDS AS C3A RECEPTOR ANTAGONISTS

Aryl substituted imidazo[4,5-c] pyridine compounds of formula (I) or pharmaceutically acceptable salt thereof are provided. These compounds are useful in pharmaceutical compositions as C3a antagonists for treating a variety of medical conditions associated with the Complement cascade.

N-1 Substituted Ethyl 4-Pyrazolecarboxylates: Synthesis and Spectroscopic Investigations

The synthesis of various N-1 substituted ethyl 4-pyrazolecarboxylates via reaction of ethyl 2-formyl-3-oxopropionate (= ethoxycarbonylmalondialdehyde) with appropriately substituted hydrazines is described.Moreover, detailed nmr-spectroscopic investigations with the title compounds are presented.