930786-01-9Relevant academic research and scientific papers
Evaluation of the tubulin-bound paclitaxel conformation: Synthesis, biology, and SAR studies of C-4 to C-3′ bridged paclitaxel analogues
Ganesh, Thota,Yang, Chao,Norris, Andrew,Glass, Tom,Bane, Susan,Ravindra, Rudravajhala,Banerjee, Abhijit,Metaferia, Belhu,Thomas, Shala L.,Giannakakou, Paraskevi,Alcaraz, Ana A.,Lakdawala, Ami S.,Snyder, James P.,Kingston, David G. I.
, p. 713 - 725 (2007/10/03)
The important anticancer drug paclitaxel binds to the β-subunit of the ββ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of in
