930804-88-9Relevant academic research and scientific papers
Free radical scavenging potential of anilinoacridines and acridinylhydrazides
Khan, Khalid Mohammed,Ali, Muhammad,Ambreen, Nida,Naz, Farzana,Arshad, Muhammad,Rao, Nosheen Akber,Perveen, Shahnaz,Shah, Zarbad
, p. 202 - 205 (2013/04/24)
Anilinoacridines and acridinylhydrazides derivatives 1-29 have been screened for their in vitro DPPH free radical scavenging activity. Compounds 19 (IC50 = 22.15 μM), 16 (IC50 = 24.95 μM), and 17 (IC50 = 34.23 μM) showed an excellent antioxidant potential superior to standard t-butyl-4-hydroxyanisole (IC50 = 44.7 μM). A structureactivity relationship has been developed and it has been found that compounds 16, 17 and 18 possess allylic carbon which upon abstraction of hydrogen radical becomes more stable mesomerically.
Facile, economical and direct synthesis of 9-anilinoacridines
Khan, Khalid M.,Rao, Nosheen A.,Ali, Muhammad,Perveen, Shahnaz,Choudhary, Muhammad Iqbal,Voelter, Wolfgang
, p. 5 - 9 (2011/04/15)
Acridines are well-known group of compounds with a wide variety of biological properties. We describe herein an expeditious approach to prepare anilinoacridine derivatives from mefenamic acid. It is the first report of a one-pot approach to anilinoacridines in good to excellent yields.
