930804-89-0Relevant academic research and scientific papers
Free radical scavenging potential of anilinoacridines and acridinylhydrazides
Khan, Khalid Mohammed,Ali, Muhammad,Ambreen, Nida,Naz, Farzana,Arshad, Muhammad,Rao, Nosheen Akber,Perveen, Shahnaz,Shah, Zarbad
, p. 202 - 205 (2013/04/24)
Anilinoacridines and acridinylhydrazides derivatives 1-29 have been screened for their in vitro DPPH free radical scavenging activity. Compounds 19 (IC50 = 22.15 μM), 16 (IC50 = 24.95 μM), and 17 (IC50 = 34.23 μM) showed an excellent antioxidant potential superior to standard t-butyl-4-hydroxyanisole (IC50 = 44.7 μM). A structureactivity relationship has been developed and it has been found that compounds 16, 17 and 18 possess allylic carbon which upon abstraction of hydrogen radical becomes more stable mesomerically.
