930805-48-4Relevant academic research and scientific papers
Novel synthesis of some 4,5,6,7,tetrahydro-benzo[6,7]cyclohepta[1,2-b] pyran, [1,2-b]pyrido [2,3-e]pyrimidine and thiazolopyridopyrimidine via cycloaddition with arylidenemalononitrile and 6-aminothiouracil
El-Gazzar,Khir El-Din,Gad
, p. 63 - 74 (2007/10/03)
1-BENZOSUBERONE reacted with arylidenemalononitriles to give the enaminonitrile moiety 1, which reacted with triethyl orthoformate to give 2, that cyclized with hydrazine hydrate to pyrimidine derivatives 3, 3′ and reacted with ammonia to form 4, which is cyclized to afford 4′. Compound 1 reacted with urea and thiourea to give 5a, b. Also, the enaminonitrile 1 reacted with formic acid to give 6. Furthermore the cycloaddition of arylidenebenzosuberone 7 with 6-aminothiouracil to afford benzocyclohepta [1,2-b]pyrido[2,3-e]pyrimidines 10. Compounds 10 reacted with halo-compounds to afford 11a-d which cyclized to form 13 and reacted with hydrazine to give 12. Also, the reaction of 10 with aldehyde in presence of chloroacetic acid afforded thiazolopyrido-pyrimidines 14.
