93102-02-4Relevant articles and documents
KRAS G12C INHIBITORS
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Paragraph 0903-0904, (2019/05/24)
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
KRAS G12C INHIBITORS
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, (2017/12/18)
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
N-(TRIMETHYLSILYLMETHYL)AMINOMETHYL ETHERS AS AZOMETHINE YLIDE SYNTHONS. A NEW AND CONVENIENT ACCESS TO PYRROLIDINE DERIVATIVES
Hosomi, Akira,Sakata, Yasuyuki,Sakurai, Hideki
, p. 1117 - 1120 (2007/10/02)
The title compounds, readily prepared from (trimethylsilylmethyl)amines, formaldehyde and an alcohol, react with electron deficient alkenes in the presence of iodosilane or silyl triflate in combination with cesium fluoride to give the corresponding pyrrolidine derivatives stereospecifically in excellent yield.