93106-25-3Relevant academic research and scientific papers
AN EFFICIENT SYNTHESIS OF CERTAIN 5-SUBSTITUTED-2'-DEOXYURIDINE 3',5'-CYCLIC MONOPHOSPHATE P-O-ALKYL(ARALKYL) ESTERS. THE CRYSTAL AND MOLECULAR STRUCTURE OF 5-IODO-2'-DEOXYURIDINE 3',5'-CYCLIC MONOPHOSPHATE P-O-METHYL ESTER WITH AXIAL METHOXY GROUP
Beres, J.,Sandor, P.,Kalman, A.,Koritsanszky, T.,Oetvoes, L.
, p. 2405 - 2414 (1984)
Some 5-alkyl- and 5-halogeno-2'-deoxyuridine 3',5'-cyclic monophosphate P-O-alkyl(aralkyl) esters have been prepared from the silver salts of the parent cyclic monophosphates and alkyl(aralkyl) iodides.The diastereomeric phosphotriesters have been characterized by spectroscopic methods.The crystal and molecular structure of 5-iodo-2'-deoxyuridine 3',5'-cyclic monophosphate P-O-methyl ester with axial methoxy group has been determined.We failed to obtain the desired triesters from the reactions of the cAMP silver salt with alkyl iodides, contrary to previous claims in the literature.
