93107-33-6 Usage
Class
Quinolone antibiotic
Explanation
It belongs to the fluoroquinolones class, which are known for their broad-spectrum antibacterial activity.
Explanation
Effective against a range of Gram-positive and Gram-negative bacteria.
Explanation
These structural components contribute to the antibacterial activity by inhibiting bacterial DNA replication and transcription.
Explanation
The chemical structure interferes with the bacteria's ability to replicate and transcribe their DNA, ultimately leading to bacterial death.
Explanation
It is used to treat a wide range of bacterial infections due to its broad-spectrum activity and effectiveness against antibiotic-resistant strains.
Explanation
1-cyclopropyl-7-(3-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid has been found to be effective against strains resistant to other antibiotics.
Spectrum of activity
Broad-spectrum
Chemical structure
Cyclopropyl ring, fluoro substituent, and piperazine moiety
Mechanism of action
Inhibition of bacterial DNA replication and transcription
Common usage
Treatment of various bacterial infections
Effectiveness against resistant strains
Yes
Check Digit Verification of cas no
The CAS Registry Mumber 93107-33-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,1,0 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 93107-33:
(7*9)+(6*3)+(5*1)+(4*0)+(3*7)+(2*3)+(1*3)=116
116 % 10 = 6
So 93107-33-6 is a valid CAS Registry Number.
93107-33-6Relevant academic research and scientific papers
Structure-activity relationships of the quinolone antibacterials against mycobacteria: Effect of structural changes at N-1 and C-7
Renau,Sanchez,Gage,Dever,Shapiro,Gracheck,Domagala
, p. 729 - 735 (2007/10/03)
The re-emergence of tuberculosis infections which are resistant to conventional drug therapy has demonstrated the need for alternative chemotherapy against Mycobacterium tuberculosis. As part of a study to optimize the quinolone antibacterials against M. tuberculosis, we have prepared a series of N-1- and C-7-substituted quinolones to examine specific structure-activity relationships between modifications of the quinolone at these two positions and activity against mycobacteria. The compounds, synthesized by literature procedures, were evaluated for activity against Mycobacterium fortuitum and Mycobacterium smegmatis as well as Gram-negative and Gram-positive bacteria. The activity of the compounds against M. fortuitum was used as a barometer of M. tuberculosis activity. The results demonstrate that (i) the activity against mycobacteria was related more to antibacterial activity than to changes in the lipophilicity of the compounds, (ii) the antimycobacterial activity imparted by the N-1 substituent was in the order tert-butyl ≥ cyclopropyl > 2,4-difluorophenyl > ethyl ? cyclobutyl > isopropyl, and (iii) substitution with either piperazine or pyrrolidine heterocycles at C-7 afforded similar activity against mycobacteria.
