931103-01-4Relevant academic research and scientific papers
Direct substitution of arylalkynyl carbinols provides access to diverse terminal acetylene building blocks
G-Dayanandan, Narendran,Scocchera, Eric W.,Keshipeddy, Santosh,Jones, Heather F.,Anderson, Amy C.,Wright, Dennis L.
, p. 142 - 145 (2017)
To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A direct route was sought whereb
Inhibitors of Dihydrofolate Reductase With Antibacterial Antiprotozoal, Antifungal and Anticancer Properties
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Page/Page column 27, (2009/05/29)
The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substitu
Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis
Pelphrey, Phillip M.,Popov, Veljko M.,Joska, Tammy M.,Beierlein, Jennifer M.,Bolstad, Erin S. D.,Fillingham, Yale A.,Wright, Dennis L.,Anderson, Amy C.
, p. 940 - 950 (2007/10/03)
The search for effective therapeutics for cryptosporidiosis and toxoplasmosis has led to the discovery of novel inhibitors of dihydrofolate reductase (DHFR) that possess high ligand efficiency: compounds with high potency and low molecular weight. Detaile
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry
Imperio, Daniela,Pirali, Tracey,Galli, Ubaldina,Pagliai, Francesca,Cafici, Laura,Canonico, Pier Luigi,Sorba, Giovanni,Genazzani, Armando A.,Tron, Gian Cesare
, p. 6748 - 6757 (2008/03/27)
Steganacin and podophyllotoxin are two naturally occurring lignans first isolated from plant sources, which share the capability to disrupt tubulin assembly. Although not strictly essential for its activity, the lactone ring on both structures represents
