93119-12-1Relevant articles and documents
Total synthesis and configurational validation of (+)-violapyrone C
Lee, Jong Seok,Shin, Junho,Shin, Hee Jae,Lee, Hwa-Sun,Lee, Yeon-Ju,Lee, Hyi-Seung,Won, Hoshik
, p. 4472 - 4476 (2014)
Gold(I)-catalyzed intramolecular 6-endo-dig cyclization of tert-butyl ynoates afforded α-pyrone cores of violapyrones. Moreover, this reaction was successfully applied to the stereospecific syntheses of (+)- and (-)-violapyrone C, which allowed the absolute configuration of natural (+)-violapyrone C to be assigned by comparison of the optical rotations. This first total synthesis, which proceeded in 22% yield over 10 steps from (S)-(-)-2-methylbutanol, features silver(I) oxide promoted monobenzylation of 1,4-butanediol, Wittig olefination, Claisen condensation, Corey-Fuchs reaction, and gold(I)-catalyzed α-pyrone synthesis. Copyright