931397-87-4

Upstream product

• 4132-28-9 2,3,4,6-tetra-O-benzyl-α-D-galactopyranose 
• 3396-99-4 methyl α-D-galactopyranoside 
• 158535-90-1 1,3,4,5-Tetra-O-benzyl-6-O-(tert-butyldimethylsilyl)-L-galactitol 
• 158570-84-4 2,3,4,6-tetra-O-benzyl-D-galactitol 
• 53008-63-2 methyl 2,3,4,6-tetra-O-benzyl-α-D-galactopyranoside 
• 100-44-7 benzyl chloride 
• 1623-08-1 phosphoric acid dibenzyl ester 
• 931397-80-7 2,3,4,5,6-penta-O-benzyl-1-O-tert-butyldimethylsilyl-D-galactitol 
• 931397-84-1 2,3,4,5,6-penta-O-benzyl-D-galactitol 
• 538-37-4 dibenzyl phosphochloridate 

Downstream Products

• 89600-16-8 galactitol-1-phosphate 

Relevant academic research and scientific papers

Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: Implication for an oxocarbenium ion intermediate in the catalytic mechanism

(Chemical Equation Presented) UDP-D-galactofuranose (2), which is essential for both cell growth and virulence in many pathogenic microorganisms, is converted from UDP-D-galactopyranose (UDP-Galp, 1) by the flavin adenine dinucleotide (FAD)-dependent enzyme UDP-galactopyranose mutase (UGM). Here, we report the synthesis of UDP-GalOH (13) and show it as an inhibitor for UGM with a binding affinity similar to that of 1. These results are more consistent with a mechanism involving an oxocarbenium ion intermediate in UGM catalysis.