93140-13-7

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-(3-methoxyphenyl)piperazin-1-yl)ethanamine is used as a psychoactive drug for its potential effects on the central nervous system, which may include mood elevation and stimulation.
Used in Neurological and Psychiatric Applications:
In the field of neurology and psychiatry, 2-(4-(3-methoxyphenyl)piperazin-1-yl)ethanamine is used as a potential therapeutic agent for various disorders. Its specific application may be directed towards conditions that could benefit from its psychoactive properties, such as depression, anxiety, or other mood disorders, although further research is necessary to establish its efficacy and safety in these areas.

Upstream product

• 16015-71-7 4-(3-methoxyphenyl)piperazine 
• 440117-88-4 2-(2-(4-(3-methoxyphenyl)-piperazin-1-yl)-ethyl)-isoindoline-1,3-dione 

Downstream Products

• 1221290-84-1 N-{2-[4-(3-methoxyphenyl)piperazin-1-yl]ethyl}-2-quinoline carboxamide 
• 1221290-97-6 N-{2-[4-(3-methoxylphenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide 
• 1221290-73-8 N-{2-[4-(3-methoxyphenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide 
• 1240266-57-2 C₂₆H₃₄N₄O₂*ClH 
• 112822-34-1 3-[2-[4-(3-methoxyphenyl)piperazin-1-yl]ethyl]furo[3,4-d]pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Small-Molecule Inhibition of the UNC119–Cargo Interaction

N-Terminal myristoylation facilitates membrane binding and activity of proteins, in particular of Src family kinases, but the underlying mechanisms are only beginning to be understood. The chaperones UNC119A/B regulate the cellular distribution and signal

Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies

A series of substituted 4-aryl-piperazine-ethyl heteroarylcarboxamides were prepared and tested in in vitro radioligand binding studies. The presence of a quinoxaline has a favourable impact in terms of serotonin 5-HT1A versus dopamine D4.2 receptor selectivity. Compounds with a 3-CF3 group at the distal phenyl ring are the most effective in terms of affinity and selectivity for 5-HT1A versus D4.2 receptors. A 4-phenyl-1,2,3,6- tetrahydropyridine in place of the corresponding 4-phenyl-piperazine side chain is also favourable not only for the affinity for 5-HT1A and D4.2 receptors but also in some cases for α2A-adrenoceptors.

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I) wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.

Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor antagonists

Phenyl-piperazines were designed and synthesized based on pharmacophore for uro-selective α1-adrenoceptor antagonists and 3D chemical database searching. Within this series, three compounds, 2, 3, and 13, showed similar or better α1-