93144-45-7Relevant academic research and scientific papers
A synthetic method for producing boron compound process and product application
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Paragraph 0027; 0028; 0029, (2018/11/22)
The invention discloses a boron amine compound synthesis technology and product application. Halogenate RX, halogenate BrBY2 and solvent are mixed and added into initiator and magnesium metal in a dropwise mode, and the temperature is kept within the range from 0 DEG C to 80 DEG C in the dropping process; after a reaction occurs, the rest is added, then the temperature is kept within the range from 20 DEG C to 80 DEG C for the reaction, saturation ammonium chloride is added for quenching, and after reduced pressure distillation, RBY2 is obtained. The technology is simple in operation, ultrlow temperature conditions, Grignard reagent concentration and the self-coupling problem are avoided, the reaction yield is high, the product stability is good, and the technology is suitable for being popularized in an industrialization mode. After the product is subjected to a derivatization reaction with KHF2 and MIDA, RBF3K and RB (MIDA) can be obtained.
One-pot synthesis process for producing boron compounds
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Paragraph 0027-0029, (2018/10/19)
The invention discloses a one-pot synthesis process for boron-amine compounds. The process comprises the steps of slowly dripping an anhydrous solvent, bromo-compounds RBr and XBY2 which are mixed into the anhydrous solvent containing metal lithium, maintaining the temperature at -20 to 20 DEG C in a dripping process, maintaining the temperature of -20 to 40 DEG C and reacting for 3-8h after the reaction initiation and the completion of adding the rest mixed solution, and separating to obtain the RBY2. An intermediate can be added with acid to be hydrolyzed to obtain organic boric acid, and reacted with diol to generate boric acid ester, or is directly conducted for coupled reaction with an aryl halogenate. The process is simple in process, few in by-product and high in reaction yield, and the ultralow temperature reaction and the dependency on the solvent by the stability of lithiated compounds can be prevented, therefore the process is applicable to industrial amplification and is beneficial for improving the core competitiveness of products.
