93150-23-3

Basic information

• Product Name: 1-[(4-benzylpiperazin-1-yl)methyl]pyrrolidine-2,5-dione
• Synonyms: 1-(4-Benzyl-piperazin-1-ylmethyl)-pyrrolidine-2,5-dione
• CAS NO: 93150-23-3
• Molecular Formula: C₁₆H₂₁N₃O₂
• Molecular Weight: 287.3568
• Mol File: 93150-23-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 472.9°C at 760 mmHg
• Flash Point: 214.9°C
• Density: 1.231g/cm³
• Vapor Pressure: 4.13E-09mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 1-[(4-benzylpiperazin-1-yl)methyl]pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-benzylpiperazin-1-yl)methyl]pyrrolidine-2,5-dione(93150-23-3)
• EPA Substance Registry System: 1-[(4-benzylpiperazin-1-yl)methyl]pyrrolidine-2,5-dione(93150-23-3)

Safety Data

• Hazardous Substances Data: 93150-23-3(Hazardous Substances Data)

Usage

Chemical class

Piperazine derivative

Psychoactive drug

Stimulant

Effects

Similar to amphetamines

Recreational use

For stimulant and euphoric effects

Commonly found in

Party pills and other recreational drugs

Mechanism of action

Increases the release of neurotransmitters such as dopamine and serotonin in the brain

Stimulant and mood-enhancing effects

Yes

Potential harmful effects

Cardiovascular and psychological side effects

Precaution

Use caution and be aware of potential risks associated with use

Upstream product

• 123-56-8 Succinimide 
• 50-00-0 formaldehyd 
• 2759-28-6 1-phenylmethylpiperazine 

Relevant articles and documents

Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs

The aim of this paper was to describe the synthesis of a library of 28 new 1,3-substituted pyrrolidine-2,5-dione as potential anticonvulsant agents. The anticonvulsant activity was evaluated using three acute models of seizures in mice (MES-maximal electroshock, scPTZ-subcutaneous pentylenetetrazole, and 6?Hz-psychomotor seizure tests). The neurotoxicity was determined by rotarod test. The most promising compound was found to be N-[{morpholin-1-yl}-methyl]-3-benzhydryl-pyrrolidine-2,5-dione (15), as it was active in the MES (ED50?=?41.0?mg/kg), scPTZ (ED50?=?101.6?kg/mg), and 6?Hz (ED50?=?45.42?mg/kg) tests. This compound displayed more beneficial protection index (PI) than antiepileptic drugs such as ethosuximide, lacosamide and valproic acid. In vitro studies for compound 15 were conducted and provided information that its possible mechanism of action is related to blocking of the neuronal voltage-sensitive sodium (site 2) and L-type calcium channels.