93159-25-2Relevant academic research and scientific papers
Enantioselective Bromolactonization of Deactivated Olefinic Acids
Jiang, Xiaojian,Liu, Shenghui,Yang, Si,Jing, Mei,Xu, Lipeng,Yu, Pei,Wang, Yuqiang,Yeung, Ying-Yeung
supporting information, p. 3259 - 3262 (2018/06/11)
A novel enantioselective bromolactonization of α,β-unsaturated ketones using bifunctional amino-urea catalysts has been developed. The scope of the reaction is evidenced by 23 examples of halolactones bearing various functionalities with up to 99% yield a
Achiral Pyridine Ligand-Enabled Enantioselective Radical Oxytrifluoromethylation of Alkenes with Alcohols
Cheng, Yong-Feng,Dong, Xiao-Yang,Gu, Qiang-Shuai,Yu, Zhang-Long,Liu, Xin-Yuan
supporting information, p. 8883 - 8886 (2017/07/17)
A conceptually novel strategy with achiral pyridine as the ancillary ligand to stabilize high-valent copper species for the first asymmetric radical oxytrifluoromethylation of alkenes with alcohols under CuI/phosphoric acid dual-catalysis has been developed. The transformation features mild reaction conditions, a remarkably broad substrate scope and excellent functional group tolerance, offering an efficient approach to a wide range of trifluoromethyl-substituted tetrahydrofurans bearing an α-tertiary stereocenter with excellent enantioselectivity. Mechanistic studies support the presumed role of the achiral pyridine as a coordinative ligand on copper metal to stabilize the key transient reaction species involved in the asymmetric induction process.
