93168-20-8

Basic information

• Product Name: 1-(3-PHENYLPROPYL)-2-THIOUREA
• Synonyms: 1-(3-PHENYLPROPYL)-2-THIOUREA
• CAS NO: 93168-20-8
• Molecular Formula: C₁₀H₁₄N₂S
• Molecular Weight: 194.3
• Mol File: 93168-20-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 111 °C
• Boiling Point: 329.6°C at 760 mmHg
• Flash Point: 153.1°C
• Appearance: /
• Density: 1.124g/cm³
• Vapor Pressure: 0.000176mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-(3-PHENYLPROPYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-PHENYLPROPYL)-2-THIOUREA(93168-20-8)
• EPA Substance Registry System: 1-(3-PHENYLPROPYL)-2-THIOUREA(93168-20-8)

Safety Data

• Hazard Codes: T
• Statements: 22-25
• Safety Statements: 22-36/37-45
• RIDADR: 2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 93168-20-8(Hazardous Substances Data)

Usage

General Description

1-(3-Phenylpropyl)-2-thiourea is a chemical compound that belongs to the class of thioureas. It is a white crystalline solid that is used in the synthesis of pharmaceuticals, agricultural chemicals, and dyes. 1-(3-PHENYLPROPYL)-2-THIOUREA has been studied for its potential biological activities, including its anti-cancer and anti-inflammatory properties. It is also used as a complexing agent for metal ions in analytical chemistry. 1-(3-Phenylpropyl)-2-thiourea is known for its potential applications in various fields and is a subject of ongoing research for its diverse properties and potential uses.

InChI:InChI=1/C10H14N2S/c11-10(13)12-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H3,11,12,13)

Upstream product

• 2038-57-5 3-Phenylpropan-1-amine 
• 861572-97-6 μ-disulfido-1,2-dithio-dicarbonic acid bis-(3-phenyl-propylamide) 
• 30684-05-0 3-phenylpropylamine hydrochloride 
• 145383-01-3 N-((3-phenylpropyl)carbamothioyl)benzamide 
• 2627-27-2 3-phenylpropyl isothiocyanate 

Downstream Products

• 1505452-73-2 2-imino-5,5-bis(4-methoxyphenyl)-3-(3-phenylpropyl)imidazolidin-4-one 
• 145231-33-0 S-<3-(4(5)-imidazolyl)propyl>-N-(3-phenylpropyl)isothiourea dihydrobromide 
• 145231-27-2 S-<2-(4(5)-imidazolyl)ethyl>-N-(3-phenylpropyl)isothiourea 

Relevant articles and documents

ANTIVIRAL COMPOUNDS AND USE THEREOF

The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.

Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: Synthesis, pharmacological evaluation, and cross-target QSAR studies

Previous studies have demonstrated that clobenpropit (N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea) binds to both the human histamine H3 receptor (H3R) and H4 receptor (H4R). In this paper, we describe the synthesis and pharmacological characterization of a series of clobenpropit analogs, which vary in the functional group adjacent to the isothiourea moiety in order to study structural requirements for H3R and H4R ligands. The compounds show moderate to high affinity for both the human H3R and H4R. Furthermore, the changes in the functional group attached to the isothiourea moiety modulate the intrinsic activity of the ligands at the H4R, ranging from neutral antagonism to full agonism. QSAR models have been generated in order to explain the H3R and H4R affinities.

Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3-receptor

The synthesis and H3-activity of a series of isothiourea analogues of histamine have been described. It has been shown that S-[2-(4(5)-imidazolyl)ethylisothiourea (VUF 8325) is a potent H3-agonist measured as the electrically evoked contraction of the guinea-pig ileum. Upon methylation of the imidazole system or the isothiourea moiety a decrease in affinity was observed leading to either weak agonists or weak antagonists. Introduction of N-(phenylalkyl) substituents at the isothiourea part gives rise to highly potent H3-antagonists. Particularly the 4-chlorobenzyl group appeared to be favourable in the series described resulting in a histamine H3-antagonist with a pA2-value of 9.9.